Probably smart w/o expert guidance.
Brugmansia
Brugmansia is a genus of seven species of flowering plants in the nightshade family Solanaceae....
Brugmansia species are amongst the most toxic of ornamental plants, containing tropane alkaloids of the type also responsible for the toxicity and deliriant effects of both jimsonweed and the infamous deadly nightshade....
Historical uses
Brugmansia contains deliriant hallucinogenic tropane alkaloids (atropine, scopolamine, and hyoscyamine) which cause delirium and hallucinations....
Brugmansia species have also traditionally been used in many South American indigenous cultures in medical preparations and as an entheogen in religious and spiritual ceremonies.[20] Medicinally, they have mostly been used externally as part of a poultice, tincture, ointment, or where the leaves are directly applied transdermally to the skin. Traditional external uses have included the treating of aches and pains, dermatitis, orchitis, arthritis, rheumatism, headaches, infections, and as an anti-inflammatory. They have been used internally much more rarely due to the inherent dangers of ingestion. Internal uses, in highly diluted preparations, and often as a portion of a larger mix, have included treatments for stomach and muscle ailments, as a decongestant, to induce vomiting, to expel worms and parasites, and as a sedative.
Several South American cultures have used Brugmansia species as a treatment for unruly children, so that they might be admonished directly by their ancestors in the spirit world, and thereby become more compliant. Mixed with maize beer and tobacco leaves, it has been used to drug wives and slaves before they were buried alive with their dead lord.
Unruly Ms.pilgrim and boy.pilgrim beware.
Maybe don't trust the experts, either:
In the Northern Peruvian Andes, shamans (curanderos) traditionally used Brugmansia species for initiation, divination, and black magic rituals. In some Latin American countries such as Colombia and Peru, members of the genus Brugmansia are reportedly used by malevolent sorcerers or "bad shamans" in some ayahuasca brews in attempt to take advantage of tourists....
Toxicity
All parts of Brugmansia are potentially poisonous, with the seeds and leaves being especially dangerous. Brugmansia are rich in scopolamine (hyoscine), hyoscyamine, and several other tropane alkaloids which can lead to anticholinergic toxidrome and delirium. Effects of ingestion can include paralysis of smooth muscles, confusion, tachycardia, dry mouth, constipation, tremors, migraine headaches, poor coordination, delusions, visual and auditory hallucinations, mydriasis, rapid onset cycloplegia, and death.
The hallucinogenic effects of Brugmansia were described in the journal Pathology as "terrifying rather than pleasurable". The author Christina Pratt, in An Encyclopedia of Shamanism, says that "Brugmansia induces a powerful trance with violent and unpleasant effects, sickening after effects, and at times temporary insanity". These hallucinations are often characterized by complete loss of awareness that one is hallucinating, disconnection from reality (psychosis), and amnesia of the episode, such as one example reported in European Archives of Psychiatry and Clinical Neuroscience of a young man who amputated his own penis and tongue after drinking only one cup of Brugmansia sanguinea tea.

billy.pilgrim beware.
In 1994 in Florida, 112 people were admitted to hospitals after ingesting Brugmansia, leading one municipality to prohibit the purchase, sale, or cultivation of Brugmansia plants....
Florida, figures

. Just touching them could have been a trip:
n 2022 The BMJ reported the following case: A woman in her 50s presented to the emergency department with blurred vision and pupil asymmetry for 3 hours. The right pupil was dilated, while the left was normal. A detailed history revealed that she had been pruning plants in her garden, when the blurred vision started. She did not complain of any other symptom. When all tests proved normal, she was finally asked to provide a photo of her garden. Brugmansia suaveolens (angel’s trumpet) was identified in the picture. On asking specific history, she reported rubbing her right eye after touching the plant’s leaves and flowers. It shows that Brugmansia is highly toxic. Even touching the leaves and flowers can transfer sufficient amounts of active principles to the hand.
Also, a lot of hippies poisoned themselves with
jimsonweed thanks to
Carlos Castaneda and inexpert prep and dosing.
... It has also been used as a hallucinogen (of the anticholinergic/antimuscarinic, deliriant type), taken entheogenically to cause intense, sacred or occult visions. It is unlikely ever to become a major drug of abuse owing to effects upon both mind and body frequently perceived as being highly unpleasant, giving rise to a state of profound and long-lasting disorientation or delirium (anticholinergic syndrome) with a potentially fatal outcome. It contains tropane alkaloids which are responsible for the psychoactive effects, and may be severely toxic.
No thanks. I was mildly tempted, but lost interest after reading about others' irl experiences. IIRC Castaneda didn't even like it much. Maaaybe if I'd met the right shaman.